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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN11
All Species:
18.18
Human Site:
S595
Identified Species:
40
UniProt:
Q06124
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06124
NP_002825.3
597
68436
S595
G
L
M
Q
Q
Q
K
S
F
R
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001164543
512
58884
S510
G
L
M
Q
Q
Q
K
S
F
R
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
K587
K
K
Q
R
S
A
D
K
E
K
S
K
G
S
L
Dog
Lupus familis
XP_534686
571
65327
Cat
Felis silvestris
Mouse
Mus musculus
P35235
597
68442
S595
G
L
M
Q
Q
Q
R
S
F
R
_
_
_
_
_
Rat
Rattus norvegicus
P41499
597
68440
S595
G
L
M
Q
Q
Q
R
S
F
R
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519242
359
41028
Chicken
Gallus gallus
Q90687
593
67964
S591
G
L
M
Q
Q
Q
K
S
F
R
_
_
_
_
_
Frog
Xenopus laevis
NP_001084076
595
68232
Q591
N
V
G
L
L
Q
Q
Q
K
S
F
R
_
_
_
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
M715
G
T
G
M
G
L
S
M
G
V
G
M
G
V
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.7
54
95.1
N.A.
99.5
98.9
N.A.
59.2
97.6
93.4
N.A.
N.A.
38.5
N.A.
N.A.
51.9
Protein Similarity:
100
85.7
70
95.1
N.A.
99.8
99.5
N.A.
60.1
98.4
95.8
N.A.
N.A.
51.3
N.A.
N.A.
65.8
P-Site Identity:
100
100
0
0
N.A.
90
90
N.A.
0
100
8.3
N.A.
N.A.
6.6
N.A.
N.A.
0
P-Site Similarity:
100
100
20
0
N.A.
100
100
N.A.
0
100
25
N.A.
N.A.
26.6
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
46
0
10
0
0
0
0
% F
% Gly:
55
0
19
0
10
0
0
0
10
0
10
0
19
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
0
0
0
0
28
10
10
10
0
10
0
0
0
% K
% Leu:
0
46
0
10
10
10
0
0
0
0
0
0
0
0
10
% L
% Met:
0
0
46
10
0
0
0
10
0
0
0
10
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
10
46
46
55
10
10
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
0
19
0
0
46
0
10
0
0
0
% R
% Ser:
0
0
0
0
10
0
10
46
0
10
10
0
0
10
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
0
0
0
0
0
0
10
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
46
46
55
55
55
% _